![]() As a result, they should be viewed with a healthy degree of skepticism. When smoked, the physically and cognitively stimulating effects become emphasized.ĭisclaimer: The effects listed below cite the Subjective Effect Index ( SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. The experience can be broken up into two stages the first half feels stimulating and entactogenic whilst the second half feels more similar to a traditional tryptamine psychedelic like psilocybin mushrooms or LSD. When ingested orally, the visual and sensory effects are reported to become more prominent. For example, SNRIs such as venlafaxine are commonly prescribed to treat depression, and the 5-HT1A agonist buspirone is prescribed primarily for treatment of anxiety.ĥ-MeO-MiPT can be taken via oral ingestion or it can be smoked. These mechanisms may help explain why there are many anecdotal reports of anti-depressant and anxiolytic effects from modest doses of this compound. While 5-MeO-MiPT binds most strongly to 5-HT1A receptors, it also shows fairly strong binding affinity to the SERT and NET, thereby acting as a moderately potent serotonin-norepinephrine reuptake inhibitor. digestive enzymes in the stomach) have also been speculated upon, though this has yet to be demonstrated scientifically. Pharmacologyįurther information: Serotonergic psychedelicĥ-MeO-MiPT's psychedelic effects are believed to come from its efficacy at the 5-HT 2A receptor as a partial agonist and additional mechanisms of action such as the inhibition of MAO (i.e. 5-MeO-MiPT is substituted at R 5 of its indole heterocycle with a methoxy (MeO) functional group CH 3O− it also contains a methyl group and an isopropyl chain bound to the terminal amine R N of its tryptamine backbone (MiPT).ĥ-MeO-MiPT is the N-substituted isopropyl homologue of 5-MeO-DMT. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R 3 to an amino group via an ethyl side chain. It is highly advised to use harm reduction practices when using this substance.ĥ-MeO-MiPT, or 5-methoxy-N-methyl-N-isopropyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. It has been sold online as a research chemical. Very little is known about the pharmacological properties, metabolism and toxicity of 5-MeO-MiPT, and it has a limited history of human use. An unpleasant "body load" is also often reported at common to high doses, marked by muscle tension and nausea. Many users report strong physical and tactile effects that serve to enhance libido and sexual pleasure. Its effects in humans was documented in Shulgin's book TiHKAL ("Tryptamines I Have Known and Loved").Īnecdotal reports describe 5-MeO-MiPT's effects as highly stimulating and mildly entactogenic, lacking in typical psychedelic visual distortions. The synthesis and pharmacology of 5-MeO-MiPT was first reported in 1985 by David Repke and Alexander Shulgin. It produces its psychoactive effects through activity at serotonin receptors in the brain. 5-MeO-MiPT is chemically related to tryptamines like 5-MeO-DMT and 5-MeO-DiPT. ![]() ![]() It is not a recommendation and should be verified with other sources for accuracy.ĥ-Methoxy-N-methyl-N-isopropyltryptamine (also known as 5-MeO-MiPT and moxy) is a lesser-known psychedelic substance of the tryptamine class. See responsible use section.ĭISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. ![]()
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